Weight loss medications have taken the world by storm, and if you’re based in London, you’ve probably heard about Ozempic’s incredible results. But there’s something new on the horizon that’s got the medical community talking.
We’ve been tracking the latest developments in weight loss treatments, and there’s one drug that’s showing results that frankly blow Ozempic out of the water. Here’s what we’ve discovered through our research and what it means for anyone serious about transforming their body.
What’s Wrong with Ozempic?
Don’t get me wrong – Ozempic has helped thousands of people lose weight. It works by mimicking GLP-1, a hormone your gut produces after eating. This hormone tells your brain you’re full, so you naturally eat less.
The problem? Our clients who’ve used Ozempic often come to us with a frustrating issue: they’ve lost weight on the scales, but they look… soft. Flabby. What we call “skinny fat.”
Here’s why this happens: when you drastically cut calories (which Ozempic makes you do), your body doesn’t just burn fat. It burns muscle too. Sometimes at an equal rate. So yes, you lose 15-20kg, but your body fat percentage barely budges.
I’ve seen this countless times in our London studio. Clients come in celebrating their weight loss, but they’re disappointed with how they look in the mirror.
Meet Retatrutide: The Triple Threat
Now here’s where things get interesting. There’s a new drug called Retatrutide that doesn’t just target one hormone pathway like Ozempic does. It targets three.
Think of it like this: if Ozempic is playing piano with one hand, Retatrutide is playing with both hands and using the pedals too.
How Retatrutide Works Differently
While Ozempic only activates GLP-1 receptors, Retatrutide hits three targets:
GLP-1 receptors – Does what Ozempic does (reduces appetite)
GIP receptors – Enhances the appetite-suppressing effects
Glucagon receptors – Here’s the kicker: this actually increases fat burning
That third mechanism is huge. Instead of just eating less, you’re actually burning more calories. It’s like having a personal trainer working inside your metabolism.
The Results Speak for Themselves
The clinical trials have been remarkable. While Ozempic typically helps people lose 10-15% of their body weight, Retatrutide participants lost up to 24.2% of their starting weight in less than a year.
But here’s what really caught my attention as a body transformation specialist: the liver fat reduction. Participants saw up to 82% reduction in liver fat. That’s not just cosmetic – that’s metabolic health improvement at a cellular level.

The London Fitness Reality Check
Here’s what most people don’t tell you about these medications: they’re not magic bullets. I’ve worked with hundreds of clients in London, and the ones who get the best results from weight loss drugs do two things religiously:
1. They Lift Weights
This isn’t negotiable. When you’re in a caloric deficit (eating less than you burn), your body will cannibalise muscle unless you give it a reason not to.
Resistance training sends a clear signal: “We need this muscle, don’t touch it.” I recommend at least two proper strength sessions per week. Not cardio, not yoga – proper resistance training.
2. They Eat Enough Protein
Most people think they’re eating enough protein. They’re not. When you’re losing weight rapidly, you need approximately 2 grams of protein per kilogram of body weight daily.
For a 70kg person, that’s 140 grams of protein every single day. That’s not easy when medications are suppressing your appetite, but it’s essential for maintaining muscle mass.
What This Means for London Residents
Retatrutide isn’t available yet – it’s still in Phase III trials. But when it does become available, it could change everything about how we approach weight loss.
The combination of superior weight loss results, better metabolic health improvements, and potentially better muscle preservation makes it extremely compelling.
The Body Transformation London Approach
Whether you use Ozempic, Retatrutide, or no medication at all, the fundamentals don’t change:
- Proper resistance training programme
- Adequate protein intake
- Sustainable caloric deficit
- Consistent sleep and stress management
We’ve helped over 500 clients in London achieve lasting body transformations, and the ones who succeed long-term always master these basics.
The medication might be the catalyst, but your training and nutrition determine whether you end up with the lean, strong physique you actually want or just a smaller version of your current self.
What’s Next?
Retatrutide represents a significant step forward in pharmaceutical weight loss support. The early results suggest it could be more effective than current options while potentially causing fewer of the muscle-wasting side effects we see with other medications.
However, no drug replaces the fundamentals of body transformation. The clients who achieve the most dramatic results in our London studio combine proper training, nutrition, and lifestyle changes.
If you’re considering weight loss medication – whether it’s Ozempic now or Retatrutide in the future – make sure you’re also investing in the training and nutrition knowledge that will help you keep the results for life.
Ready to transform your body the right way? At BTX, we specialise in helping busy Londoners achieve lasting results through science-based training and nutrition. Whether you’re using weight loss medications or going the natural route, we’ll help you build the lean, strong physique you actually want. Contact us today to book your consultation.
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